Homeostasis’ refers to the maintenance of constant internal environment of the body (homeo = same; stasis = standing). Importance of internal environment was notified by the great biologist of 19th century Claude Bernard. He enlightened the fact that multicellular organisms including man live in a perfectly organized and controlled internal environment, which he called ‘milieu interieur’. The word ‘homeostasis’ was introduced by Harvard Professor, Walter B Cannon in 1930. Internal environment in the body is the extracellular fluid (ECF) in which the cells live. It is the fluid outside the cell and it constantly moves throughout the body. It includes blood, which circulates in the vascular system and fluid present in between the cells called interstitial fluid. ECF contains nutrients, ions and all other substances necessary for the survival of the cells. Normal healthy living of large organisms including human beings depends upon the constant maintenance of internal environment within the physiological limits. If the internal environment deviates beyond the set limits, body suffers from malfunction or dysfunction. Therefore, the ultimate goal of an organism is to have a normal healthy living, which is achieved by the maintenance of internal environment within set limits. The concept of homeostasis forms basis of physiology because it explains why various physiological functions are to be maintained within a normal range and in case if any function deviates from this range how it is brought back to normal. Understanding the concept of homeostasis also forms the basis for clinical diagnostic procedures. For example, increased body temperature beyond normal range as in the case of fever, indicates that something is wrong in the heat production-heat loss mechanism in the body. It induces the physician to go through the diagnostic proceedings and decide about the treatment.

For the functioning of homeostatic mechanism, the body must recognize the deviation of any physiological activity from the normal limits. Fortunately, body is provided with appropriate detectors or sensors, which recognize the deviation. These detectors sense the deviation and alert the integrating center. The integrating center immediately sends information to the concerned effectors to either accelerate or inhibit the activity so that the normalcy is restored.


One or more systems are involved in homeostatic mechanism of each function. Some of the functions in

which the homeostatic mechanism is well established are given below:

1. The pH of the ECF has to be maintained at the critical value of 7.4. The tissues cannot survive if

it is altered. Thus, the decrease in pH (acidosis) or increase in pH (alkalosis) affects the tissues

markedly. The respiratory system, blood and kidney help in the regulation of pH.

2. Body temperature must be maintained at 37.5°C. Increase or decrease in temperature alters the metabolic activities of the cells. The skin, respiratory system, digestive system, excretory system,

skeletal muscles and nervous system are involved in maintaining the temperature within normal limits.

3. Adequate amount of nutrients must be supplied to the cells. Nutrients are essential for various

activities of the cell and growth of the tissues. These substances also form the source of energy required

for various activities of the cells. Nutrients must be digested, absorbed into the blood and supplied to

the cells. Digestive system and circulatory system play major roles in the supply of nutrients.

4. Adequate amount of oxygen should be made available to the cells for the metabolism of the

nutrients. Simultaneously, the carbon dioxide and other metabolic end products must be removed.

Respiratory system is concerned with the supply of oxygen and removal of carbon dioxide. Kidneys and

other excretory organs are involved in the excretion of waste products.

5. Many hormones are essential for the metabolism of nutrients and other substances necessary for the

cells. Hormones are to be synthesized and released from the endocrine glands in appropriate quantities

and these hormones must act on the body cells appropriately. Otherwise, it leads to abnormal signs

and symptoms.

6. Water and electrolyte balance should be maintained optimally. Otherwise it leads to dehydration or

water toxicity and alteration in the osmolality of the body fluids. Kidneys, skin, salivary glands and

gastrointestinal tract take care of this.

7. For all these functions, the blood, which forms the major part of internal environment, must be normal.

It should contain required number of normal red blood cells and adequate amount of plasma with

normal composition. Only then, it can transport the nutritive substances, respiratory gases, metabolic

and other waste products.

8. Skeletal muscles are also involved in homeostasis. This system helps the organism to move around in

search of food. It also helps to protect the organism from adverse surroundings, thus preventing damage

or destruction.

9. Central nervous system, which includes brain and spinal cord also, plays an important role in homeostasis. Sensory system detects the state of the body or surroundings. Brain integrates and

interprets the pros and cons of these information and commands the body to act accordingly through

motor system so that, the body can avoid the damage.

10. Autonomic nervous system regulates all the vegetative functions of the body essential for


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